Our Work Featured on the Cover of Trends in Endocrinology & Metabolism!

The cover illustration reflects the central theme of our article: the hidden complexity of liver metabolism and the limitations of traditional bulk measurements. A focused beam of light illuminating a diseased liver represents genetically encoded fluorescent biosensors, which allow metabolic processes to be visualized in living cells with single-cell resolution.

These technologies are changing how we study liver metabolism by revealing cellular differences and dynamic changes in key metabolic pathways, including glycolysis, lipid oxidation, and the tricarboxylic acid (TCA) cycle. This level of resolution is particularly valuable for understanding metabolic reprogramming in obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and hepatocellular carcinoma.

The damaged stone wall in the artwork represents the constraints of conventional approaches, which often overlook the metabolic diversity within tissues. The beam of light symbolizes the ability of biosensors to uncover previously inaccessible pathways and provide a clearer view of how individual cells adapt during disease.

We thank the editorial team at Trends in Endocrinology & Metabolism, the leading staff members Israel Pérez Chávez and Eduardo H. Gilglioni, our collaborators, and all contributors to this work for this recognition.

Cover artwork by Priyanka Oberoi.